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egg extracts, conserved serine-864 and serine-895 are phosphorylated upon replication worry and this phosphorylation is required for checkpoint activation. CKBD is required for checkpoint activation, plus a phosphopeptide that contains CKBD is adequate for binding to Chk1.
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The connection concerning Cdc7 functionality and Chk1 activation in vivo is powerful, but the info relating to mechanism, particularly directness of Claspin like a Cdc7 target, were tougher to glean.
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Thank you for submitting your post "Cdc7 activates replication checkpoint by phosphorylating the Chk1 binding domain of Claspin" for thought by eLife
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A 3rd protein usually takes on this job, but its id is controversial. New investigate details to your protein called casein kinase one, but it had been check here also attainable that One more protein, Cdc7 kinase, could be included.
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We as a result examined the levels of Cdc7 and CK1γone proteins in numerous cell traces. By comparing the western signals of The complete cell extracts from a hard and fast variety of various cells with those of the Management protein samples of recognized amount, we approximated the numbers of Cdc7 and CK1γone molecules per mobile. The outcome point out that the figures of Cdc7 molecules in most cancers cells are 10–fifty fold over those in non-most cancers cells.
The response of cells to DNA harm and DNA replication tension is a major location of investigation, and signal transduction related to these procedures differs involving cancer and usual cells. A number of protein kinases are already more info noted to be associated with the activation of the Chk1 kinase in human cells, as Element of the ATR-Claspin mediated signally pathway.
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